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May-June 2020

Volume: 108 Number: 3

Malaria is a devastating disease transmitted from person to person by mosquitoes. It kills more than 400,000 people per year, more than half of those deaths being children 5 years old or younger. CRISPR (clustered regularly interspaced short palindromic repeats) is a new gene-editing technology that acts like a pair of molecular scissors: It is used to “cut and paste” DNA sequences to alter gene function. In “Gene Editing and the War Against Malaria” (pages 162–169), Ethan Bier and Elliott Sober describe how biologists can now alter genes in a malaria-transmitting mosquito population by engineering a CRISPR gene drive, which mimics a natural evolutionary process. With this tool, a new gene can be inserted into the genome so that the alteration is rapidly passed down to successive sexually reproducing generations. Two gene-drive strategies have been found feasible: The first drives a local malaria-transmitting population to extinction; the second renders mosquitoes unable to transmit malaria, which breaks the malaria transmission cycle. (Illustration by Barbara Aulicino.)

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  • January-February - 2020 - Volume: 108 - Number: 1

    January-February 2020

    Volume: 108 Number: 1

    • "How Climate Science Could Lead to Action," by Samantha Jo Fried

    • "What’s Everything Made Of?" by Charles T. Sebens

    • "Why Brewers Choose Barley," by Rob DeSalle and Ian Tattersall

  • November-December - 2019 - Volume: 107 - Number: 6

    November-December 2019

    Volume: 107 Number: 6

    • "The Decline of Oregon's Rare Sand Dune Lakes," by Doug W. Larson

    • "Expanding Consciousness," by Lars Chittka and Catherine Wilson

    • "Comets Are Not Forever," by Michael Werner and Peter Eisenhardt

  • September-October - 2019 - Volume: 107 - Number: 5

    September-October 2019

    Volume: 107 Number: 5

    • "A Delta in Peril," by Meraz Mostafa, Naznin Nasir, M. Feisal Rahman, and Saleemul Huq

    • "Dying for a Drink," by Marcus D. King

    • "Sustaining the Last Rivers," by Jeffrey J. Opperman, Sharon Baruch-Mordo, Juan Pablo Carvallo, Daniel Kammen, Joe Kiesecker, and Chris Weber

    • "Thirsty City on a Lake," by Manuel Perló Cohen and Loreta Castro-Reguera Mancera

  • July-August - 2019 - Volume: 107 - Number: 4

    July-August 2019

    Volume: 107 Number: 4

    • "What Mirrors Do," by Michael C. Corballis

    • "A Hawaiian Renaissance That Could Save the World," by Sam ʻOhukaniʻōhiʻa Gon III and Kāwika B. Winter

    • "Contextualizing Cave Art" by Bruno David

  • May-June - 2019 - Volume: 107 - Number: 3

    May-June 2019

    Volume: 107 Number: 3

    • "Connecting Habitats to Prevent Species Extinctions," by Stuart L. Pimm and Clinton N. Jenkins

    • "The Flavor of Serendipity," by Gary K. Beauchamp

    • "Huh? Is That a Universal Word?" by N. J. Enfield

  • March-April - 2019 - Volume: 107 - Number: 2

    March-April 2019

    Volume: 107 Number: 2

    • "Renewed Hope for Coastal Marshes in Louisiana," by Paige Byerly, Bethann Garramon Merkle, and Megan Hepner

    • "Knit and Stretch," by Samuel Poincloux

    • "The Root of Misaligned Jaws," by Sandra Kahn and Paul R. Ehrlich

  • January-February - 2019 - Volume: 107 - Number: 1

    January-February 2019

    Volume: 107 Number: 1

    • "Estimating Ancient Populations by Aerial Survey," by William E. Carter, Ramesh L. Shrestha, and Juan Carlos Fernandez-Diaz

    • "Is Wildlife Conservation Policy Based in Science?" by Kyle A. Artelle

    • "Random Paths to Frequency Hopping," by Tony Rothman

  • November-December - 2018 - Volume: 106 - Number: 6

    November-December 2018

    Volume: 106 Number: 6

    • "America's Cat Is on the Comeback," by Michelle LaRue

    • "Going Nowhere Fast," by Ben Allanach

    • "Collecting Evolution," by Matthew J. James

  • September-October - 2018 - Volume: 106 - Number: 5

    September-October 2018

    Volume: 106 Number: 5

    • "Gravitational Wave Astronomy," by Joey Shapiro Key and Tyson Littenberg

    • "Why Do Galaxies Start Out as Cosmic Pickles?" by Joel Primack

    • "Gaia Reveals the Milky Way," by Ronald Drimmel

  • July-August - 2018 - Volume: 106 - Number: 4

    July-August 2018

    Volume: 106 Number: 4

    • "Mystery of the Lost Reptiles" by Daniel T. Ksepka

    • "High-Tech Homelessness," by Virginia Eubanks

    • "Maxwell Zombies: Conjuring the Thermodynamic Undead," by Daniel P. Sheehan

    • "Learning to See," by Gene Tracy