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September-October 2025

Volume: 113 Number: 5

When HIV enters a cell, its genome (white strand, top right corner) incorporates into the cell’s genome in the nucleus. As the cell activates its genes, the virus’s genes turn on too. The cell then transcribes the viral RNA (yellow squiggles), which moves through the cell and is used to synthesize the virus’s proteins (red). As the viral RNA and proteins accumulate at the cell’s membrane, the immature viral particles bud off, taking with them pieces of the membrane and its proteins (magenta). Viral enzymes finish processing the proteins to create the HIV capsid (the protein shell that encloses the virus’s genome) leading to a fully mature virus particle. In “A Revolutionary Drug to Treat and Prevent HIV Infection,” author John Raul Somoza describes the process of developing a new drug, lenacapavir, that interferes with capsid assembly and movement. (Cover illustration by David S. Goodsell, B-HIVE Center, RCSB Protein Data Bank and Scripps Research. doi:10.2210/rcsb_pdb/goodsell-gallery-047)

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  • July-August - 2000 - Volume: 88 - Number: 4

    July-August 2000

    Volume: 88 Number: 4

    • "Depression and the Birth and Death of Brain Cells," by Barry L. Jacobs, Henriette van Praag and Fred H. Gage

    • "Testing Ecological Patterns," by James G. Sanderson

    • "The Heart of the Milky Way," by Fulvio Melia

    • "Mathematical Devices for Getting a Fair Share," by Theodore P. Hill

    • "Measuring Success in Conservation," by Leah R. Gerber, Douglas P. DeMaster and Simona Perry Roberts

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  • May-June - 2000 - Volume: 88 - Number: 3

    May-June 2000

    Volume: 88 Number: 3

    • "Reengineering the Electric Grid," by Thomas J. Overbye

    • "Biomolecules and Nanotechnology," by David S. Goodsell

    • "Vision and the Coding of Natural Images," by Bruno A. Olshausen and David J. Field

    • "Mitochondrial DNA and the Peopling of the New World," by Theodore G. Schurr

    • "Superconducting Cosmic Strings,," by Alejandro Gangui

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  • March-April - 2000 - Volume: 88 - Number: 2

    March-April 2000

    Volume: 88 Number: 2

    • "Tracking Down a Cheating Gene," by Barry Ganetzky

    • "Simulating Solar Prominences in the Laboratory," by Paul M. Bellan

    • "What Do Animals Think About Numbers?" by Marc D. Hauser

    • "Foams and Honeycombs," by Erica G. Klarreich

    • "Electroshock Revisited," by Max Fink

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  • January-February - 2000 - Volume: 88 - Number: 1

    January-February 2000

    Volume: 88 Number: 1

    • "Impacts of Industrial Animal Production on Rivers and Estuaries," by Michael A. Mallin

    • "Connecting Materials Science and Music in Steel Drums," by Lawrence E. Murr and Everaldo Ferreyra Tello

    • "Fishing Down Aquatic Food Webs," by Daniel Pauly, Villy Christensen, Rainer Froese and Maria Lourdes Palomares

    • "The Galactic Environment of the Sun," by Priscilla Frisch

    • "Fifty Years of Radiocarbon Dating," by R. E. Taylor

    • "The Women Scientists of Bologna," by Maria Cieslak-Golonka and Bruno Morten

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  • November-December - 1999 - Volume: 87 - Number: 6

    November-December 1999

    Volume: 87 Number: 6

    • "Antarctica's Lake Vostok," by Martin J. Siegert

    • "Prokaryotes," by Michael Hoppert and Frank Mayer

    • "Water, Migration and the Serengeti Ecosystem," by Eric Wolanski, Emmanuel Gereta, Markus Borner and Simon Mduma

    • "How Will Climate Change Affect Human Health?," by Pim Martens

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  • September-October - 1999 - Volume: 87 - Number: 5

    September-October 1999

    Volume: 87 Number: 5

    • "Cliffs as Natural Refuges," by Douglas W. Larson (Plant Ecology), Uta Matthes and Peter E. Kelly

    • "Deconstructing the Milky Way Galaxy," by Henry Freudenreich

    • "Stingless-Bee Communication," by James C. Nieh

    • "Conformal Mappings," by Steven G. Krantz

    • "Ancient DNA," by George Poinar, Jr.

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  • July-August - 1999 - Volume: 87 - Number: 4

    July-August 1999

    Volume: 87 Number: 4

    • "Rapid Climate Change," by Kendrick Taylor

    • "DNA Vaccines as Cancer Treatment," by Edward P. Cohen, Edwin F. de Zoeten and Morton Schatzman

    • "Polarized Starlight and the Handedness of Life," by Stuart Clark

    • "The Mystery of Ticklish Laughter," by Christine R. Harris

    • "Human Embryonic Stem-Cell Research: Science and Ethics," by Shirley Wright

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  • May-June - 1999 - Volume: 87 - Number: 3

    May-June 1999

    Volume: 87 Number: 3

    • "Neutrino Oscillations," by Kenji Kaneyuki and Kate Scholberg

    • "Millipeds," by William A. Shear

    • "Gene Therapy," by Eric B. Kmiec

    • "Light-Reflection Strategies," by Andrew Parker

    • "The New Science of Finance," by Don M. Chance and Pamela P. Peterson

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  • March-April - 1999 - Volume: 87 - Number: 2

    March-April 1999

    Volume: 87 Number: 2

    • "The Evolution of Hemoglobin," by Ross Hardison

    • "The Gestural Origins of Language," by Michael C. Corballis

    • "Mantle Plumes and Mountains," by J. Brendan Murphy, Gary L. Oppliger, George Brimhall and Andrew Hynes

    • "Walking on Water," by Robert B. Suter

    • "Early Canid Domestication: The Farm-Fox Experiment," by Lyudmila N. Trut

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  • January-February - 1999 - Volume: 87 - Number: 1

    January-February 1999

    Volume: 87 Number: 1

    • "Molecular Conservation Genetics," by Mary V. Ashley

    • "Rocks at the Mars Pathfinder Landing Site," by Harry Y. McSween, Jr. and Scott L. Murchie

    • "Foraging by Seabirds on an Olfactory Landscape," by Gabrielle Nevitt

    • "Lead in the Inner Cities," by Howard Mielke

    • "Knowledge Discovery and Data Mining," by Carla E. Brodley, Terran Lane, Timothy M. Stough

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