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Victory for Crowdsourced Biomolecule Design
from Nature News
Obsessive gamers' hours at the computer have now topped scientists' efforts to improve a model enzyme, in what researchers say is the first crowdsourced redesign of a protein.
The online game Foldit, developed by teams led by Zoran Popovic, director of the Center for Game Science, and biochemist David Baker, both at the University of Washington in Seattle, allows players to fiddle at folding proteins on their home computers in search of the best-scoring (lowest-energy) configurations.
The researchers have previously reported successes by Foldit players in folding proteins, but the latest work moves into the realm of protein design, a more open-ended problem. By posing a series of puzzles to Foldit players and then testing variations on the players' best designs in the lab, researchers have created an enzyme with more than 18-fold higher activity than the original. The work is published today in Nature Biotechnology.
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