SCIENCE IN THE NEWS DAILY
Prion Diseases Hide Out in the Spleen
from Nature News
Prion diseases such as bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) are able to jump species much more easily than previously thought. A study published in Science today [January 26] shows that in mice, prions introduced from other species can replicate in the spleen without necessarily affecting the brain.
The study reinforces the concern that thousands of people in the United Kingdom might be silent carriers of prion infection, potentially able to pass a lethal form of the disease to others through surgery or blood transfusions.
Prions are infectious pathogens, primarily composed of the misfolded form of a protein called PrP. Normal PrP molecules that are converted into the misshapen type then aggregate in the brain to form hard, insoluble clumps--with fatal consequences.
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