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Mystery of HIV Carriers Who Don't Contract AIDS

from Scientific American

More than half a million people in the U.S. have died from HIV infection, and more than a million currently live with the virus, but a relative handful of people infected with HIV never get treatment for it and never get sick from it. The immune systems of this small population--perhaps 50,000 Americans--somehow control the virus for long periods of time.

Of course, there is typically a bell curve of response to any disease, but figuring out how these people control the virus is one of the most vexing mysteries of the AIDS pandemic. Solving it might unlock new ways to prevent and treat HIV infection, and now several research teams are going after the answer.

... "Long-term nonprogressors" is a category of persons whose disease progresses less rapidly than average. Researchers originally used the term broadly but now they have been able to tease out two subsets of patients within a hierarchy...

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