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A Geneticist's Research Turns Personal

from the New York Times (Registration Required)

Human genome sequencing is already helping researchers find new treatments for illness. Now an unusual case study suggests that the benefits of sequencing may be enhanced in combination with detailed blood tests.

The case involves Michael Snyder, a geneticist who was both the lead author and the subject of a study on genomics reported in the journal Cell. The study began with the sequencing of Dr. Snyder's genome, which showed that he was at high risk for Type 2 diabetes. Then the research team did extensive blood tests every two months or more, keeping track of 40,000 molecules in Dr. Snyder's cells. About midway into the 14-month study, analyses showed that Dr. Snyder had indeed developed diabetes.

"My genome did predict I was at risk," he said, "and because I was watching out, I detected the illness pretty early." The research team monitored the molecular changes closely as the disease developed. The illness was treated successfully while in its early stages, long before it might have been if Dr. Snyder had relied on a conventional visit to the doctor.

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