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In a Malaria Hot Spot, Resistance to a Key Drug

from Time

Every year, thousands of workers arrive at the sapphire and ruby mines of Pailin, Cambodia, risking their lives to unearth gems in the landmine-ridden territory. Soon, however, they could be the ones to put millions of others at risk.

On the Thai-Cambodian border, a rogue strain of malaria has started to resist artemisinin, the only remaining effective drug in the world's arsenal against malaria's most deadly strain, Plasmodium falciparum.

For six decades, malaria drugs like chloroquine and mefloquine have fallen impotent in this Southeast Asian border area, allowing stronger strains to spread to Burma, India and Africa. But this time there's no new wonder drug waiting in the wings. "It would be unspeakably dire if resistance formed to artemisinin," says Amir Attaran, a professor of law and medicine at the University of Ottawa who has written extensively on malaria issues.

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