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Thalidomide's Partner in Crime
from ScienceNOW Daily News
Thalidomide ranks as one of the worst pharmaceutical disasters in modern history. Prescribed as an antinausea drug for pregnant women in the late 1950s and early 1960s, it caused severe birth defects in as many as 10,000 children before it was yanked from the market. Half a century later, scientists are still not sure exactly how the drug does so much damage, which includes shortened arms and legs, ear deformities, and malformations in the digestive system.
Now, for the first time, researchers have found a specific protein that binds to thalidomide and may help explain its devastating effects on fetal development. The find could help scientists develop less-toxic versions of the drug, which has helped combat the cancer multiple myeloma and complications of leprosy.
Because of its use in those hard-to-treat diseases, thalidomide is still causing birth defects today--especially in Africa and South America where leprosy still rages. (In the United States, people given thalidomide for myeloma are instructed to use multiple forms of birth control and take frequent pregnancy tests.) Scientists are therefore eager to understand exactly how thalidomide does its damage so that they can preserve the benefits of the drug without its hazards.
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