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Gene Networks Underlie Disease?
from the Scientist (Registration Required)
An international group of researchers has developed a novel method for identifying entire networks of genes and their association to disease, providing a more accurate picture of the genetic risks associated with specific diseases than single genes can provide.
In the proof-of-concept paper published Thursday in Nature, the researchers used an integrated genomics approach to identify a network of inflammatory and anti-viral genes, present in both rats and humans, that seems to play a role in autoimmune diseases such as type 1 diabetes.
"It is an important discovery," said Constantin Polychronakos, an endocrinologist at the McGill University Health Center who was not involved in the study. "Instead of looking at individual genes and trying to make sense out of it, they were looking at whole networks of genes."
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