Logo IMG
HOME > My Amsci > Restricted Access

Restricted Access The content you've requested is available without charge only to active Sigma Xi members and American Scientist subscribers.

If you are an active member or an individual subscriber, please log in now in order to access this article.

If you are not a member or individual subscriber, you can:


Figure 1. Skeletal muscle...Click to Enlarge Image

Most people think of skeletal muscle as the tissue that makes us move, and when they think of skeletal muscle and exercise, they think of Olympians. Both perceptions grossly oversimplify this most plentiful of all tissues in the human body. Genes in skeletal muscle are exquisitely responsive to changes in loads, in some cases responding with protein production within minutes of the onset of exercise. The actions of these proteins explain adaptations to exercise as wide ranging as long-term improvements in fitness and extremely short-term protection of the nervous system from glycogen depletion. Further, their absence in sedentary people may also help cause obesity, type-2 diabetes and even some cancers. The authors hypothesize that these systems, refined through millennia in our hunter-gatherer ancestors, have become maladaptive in the past few centuries as our physical activity levels have plummeted.

Connect With Us:


Subscribe to Free eNewsletters!

Read Past Issues on JSTOR

JSTOR, the online academic archive, contains complete back issues of American Scientist from 1913 (known then as the Sigma Xi Quarterly) through 2005.

The table of contents for each issue is freely available to all users; those with institutional access can read each complete issue.

View the full collection here.

RSS Feed Subscription

Receive notification when new content is posted from the entire website, or choose from the customized feeds available.

Write for American Scientist

Review our submission guidelines.

Subscribe to American Scientist