Subscribe
Subscribe
MY AMERICAN SCIENTIST
LOG IN! REGISTER!
SEARCH
 
Logo IMG
HOME > My Amsci > Restricted Access

Protein Folding and Misfolding



Restricted Access The content you've requested is available without charge only to active Sigma Xi members and American Scientist subscribers.


If you are an active member or an individual subscriber, please log in now in order to access this article.

If you are not a member or individual subscriber, you can:



Abstract:

Figure 6. Ribbon drawings . . .Click to Enlarge Image

Protein chains can fold into an enormous range of structures, but a few basic localized folds, or secondary structures, are widespread. The most common of these are alpha helices and beta sheets. The sequence of amino acids in a protein generally determines its three-dimensional shape, but researchers are still struggling to decipher the underlying grammar that links sequence to structure. Even understanding the formation of a basic beta-sheet structure has been difficult. Amino acids that make up a structure are often far apart in sequence, and understanding their long-range chemical interactions is an intricate problem. Recent experiments with one protein—the tailspike protein of a virus that infects Salmonella—have contributed a great deal to the understanding of how a specific kind of beta-sheet structure, the beta coil, forms. This is a step toward solving the protein-folding problem—or how sequence determines fold. This remains an important problem to solve since the precise folding of a cell’s thousands of proteins is crucial to their function and a cell’s life.


Connect With Us:

Facebook Icon Sm Twitter Icon Google+ Icon Pinterest Icon RSS Feed

Subscribe to Free eNewsletters!

  • American Scientist Update

  • An early peek at each new issue, with descriptions of feature articles, columns, and more. Every other issue contains links to everything in the latest issue's table of contents.

  • Scientists' Nightstand: Holiday Special!

  • News of book reviews published in American Scientist and around the web, as well as other noteworthy happenings in the world of science books.

    To sign up for automatic emails of the American Scientist Update and Scientists' Nightstand issues, create an online profile, then sign up in the My AmSci area.


Read Past Issues on JSTOR

JSTOR, the online academic archive, contains complete back issues of American Scientist from 1913 (known then as the Sigma Xi Quarterly) through 2005.

The table of contents for each issue is freely available to all users; those with institutional access can read each complete issue.

View the full collection here.


RSS Feed Subscription

Receive notification when new content is posted from the entire website, or choose from the customized feeds available.


Write for American Scientist

Review our submission guidelines.


Subscribe to American Scientist