Logo IMG
HOME > My Amsci > Restricted Access

Restricted Access The content you've requested is available without charge only to active Sigma Xi members and American Scientist subscribers.

If you are an active member or an individual subscriber, please log in now in order to access this article.

If you are not a member or individual subscriber, you can:


Figure 7. Replication patternsClick to Enlarge Image

Many biologists continually seek a better view of chromosomes. Their generally twisted and tangled state, however, defies most simple approaches to visualizing this structure. As the authors explain, a technique called molecular combing can neatly arrange chromosomes in straight lines along a piece of glass. Specific sequences of stretched DNA can then be marked with fluorescent labels. They have applied this combination of techniques to several problems, including measuring the distance between gene loci, detecting deletions that arise in many disease states, revealing the temporal and spatial pattern of DNA replication and finding chromosomal amplifications associated with oncogenes, which promote cell transformations in cancer. Through these applications and others, molecular combing promises improved views of many aspects of chromosomes.

Connect With Us:


Subscribe to Free eNewsletters!

Read Past Issues on JSTOR

JSTOR, the online academic archive, contains complete back issues of American Scientist from 1913 (known then as the Sigma Xi Quarterly) through 2005.

The table of contents for each issue is freely available to all users; those with institutional access can read each complete issue.

View the full collection here.

RSS Feed Subscription

Receive notification when new content is posted from the entire website, or choose from the customized feeds available.

Write for American Scientist

Review our submission guidelines.

Subscribe to American Scientist