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January-February 2000 (Volume 88, Number 1)

• "Impacts of Industrial Animal Production on Rivers and Estuaries," by Michael A. Mallin
• "Connecting Materials Science and Music in Steel Drums," by Lawrence E. Murr and Everaldo Ferreyra Tello
• "Fishing Down Aquatic Food Webs," by Daniel Pauly, Villy Christensen, Rainer Froese and Maria Lourdes Palomares
• "The Galactic Environment of the Sun," by Priscilla Frisch
• "Fifty Years of Radiocarbon Dating," by R. E. Taylor
• "The Women Scientists of Bologna," by Maria Cieslak-Golonka and Bruno Morten

March-April 2000 (Volume 88, Number 2)

• "Tracking Down a Cheating Gene," by Barry Ganetzky
• "Simulating Solar Prominences in the Laboratory," by Paul M. Bellan
• "What Do Animals Think About Numbers?" by Marc D. Hauser
• "Foams and Honeycombs," by Erica G. Klarreich
• "Electroshock Revisited," by Max Fink

May-June 2000 (Volume 88, Number 3)

• "Reengineering the Electric Grid," by Thomas J. Overbye
• "Biomolecules and Nanotechnology," by David S. Goodsell
• "Vision and the Coding of Natural Images," by Bruno A. Olshausen and David J. Field
• "Mitochondrial DNA and the Peopling of the New World," by Theodore G. Schurr
• "Superconducting Cosmic Strings," by Alejandro Gangui

July-August 2000 (Volume 88, Number 4)

• "Depression and the Birth and Death of Brain Cells," by Barry L. Jacobs, Henriette van Praag and Fred H. Gage
• "Testing Ecological Patterns," by James G. Sanderson
• "The Heart of the Milky Way," by Fulvio Melia
• "Mathematical Devices for Getting a Fair Share," by Theodore P. Hill
• "Measuring Success in Conservation," by Leah R. Gerber, Douglas P. DeMaster and Simona Perry Roberts

September-October 2000 (Volume 88, Number 5)

• "The Search for QCD Exotics," by Alex R. Dzierba, Curtis A. Meyer and Eric S. Swanson
• "Pollination of Cacti in the Sonoran Desert," by Theodore H. Fleming
• "A New Urban Ecology," by James P. Collins, Ann Kinzig, Nancy B. Grimm, William F. Fagan, Diane Hope, Jianguo Wu and Elizabeth Borer
• "Brain Plasticity and Recovery from Stroke," by Nina P. Azari and Rüdiger J. Seitz
• "Andrew Ellicott Douglass and the Big Trees," by Donald J. McGraw

November-December 2000 (Volume 88, Number 6)

• "White Dwarf Stars," by Steven Kawaler and Michael Dahlstrom
• "Gene Chips and Functional Genomics," by Hisham Hamadeh and Cynthia Afshari
• "The Power of Sound," by Steven L. Garrett and Scott Backhaus
• "Scientific Publication Trends and the Developing World," by Antonio Gálvez, Mercedes Maqueda, Manuel Martínez-Bueno and Eva Valdivia
• "The Case of Agent Gorbachev," by Kristie Macrakis