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The Widening Gyrus

Concert pianists could be model organisms for studying the physiological basis of intellectual greatness

Charles T. Ambrose


Concert pianists represent a human model of highly integrated motor activity. The primary motor area for the hands and arms is in the precentral gyrus of the frontal lobe. If an fMRI of this area in trained pianists reveals increased blood flow, we may question whether it is due to neocapillaries induced earlier by an angiogenic peptide—similar to the macrophage-derived angiogenesis factor or tumor necrosis factor alpha. Angiogenesis has been studied extensively in certain brain tumors (glioblastomas) and recently in cases of stroke—both pathological conditions. This essay suggests a nonpathological function for angiogenesis in the healthy, stimulated brain.

Searching for a talent-linked angiogenic peptide (or peptides) in neurogenesis would be difficult using master pianists as the model. Concert performers are rare and revered and might resent neurochemical probing of their brains. Furthermore, the development of their enhanced motor skills takes place over many years of practice. This long interval might make identifying a putative angiogenic peptide difficult if it were present and active only with the inception of the new capillaries. On the other hand, it seems plausible, based on work such as Nottebohn’s birdsong studies mentioned above, that maintaining a high level of pianistic skill requires continuous stimulation by an angiogenic factor for preservation of an enhanced local capillary bed.

My fascination with this subject developed after attending a private performance by Dr. Paul Bachner, chair of pathology at the University of Kentucky and a gifted concert pianist. It would be interesting, if intrusive and perhaps unwelcomed, to determine if his pianistic skill is linked to high levels of a cerebral angiogenic peptide.


  • Altman, J. 1962. Are new neurons formed in the brains of adult mammals? Science 135:1127–1128.
  • Bailey, C. H., D. Bartsch and E. R. Kandel. 1996. Toward a molecular definition of long-term memory storage. Proceedings of the National Academy of Sciences of the U.S.A 93:13445–13452.
  • Bailey, D. K. 2004. In the place space. Science 305:1245–1246.
  • Buonomano, D. V., and M. M. Merzenich. 1998. Cortical plasticity, from synapses to maps. Annual Review of Neuroscience 21: 149–186.
  • Burrell, B. 2004. Postcards from the Brain Museum. New York: Broadway Books.
  • Chopp, M., Z. G. Zhang and Q. Jiang. 2007. Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke. Stroke 38:827–831.
  • Darwin, I. F., ed. 1887. The Life and Letters of Charles Darwin. Two volumes. New York: D. Appleton and Co.
  • Diamond, M., A. B. Scheibel, G. M. Murphy and T. Harvey. 1985. On the brain of a scientist: Albert Einstein. Experimental Neurology 988:198–204.
  • Donaldson, H. H. 1928. A study of the brains of three scholars. Journal of Comparative Neurology 46:1–84.
  • Draganski, B. , C. Gaser, V. Busch, G. Schuierer, U. Bogdahn and A. May. 2004. Changes in grey matter induced by training. Nature 427:311–312.
  • Elbert, T., C. Pantev, C. Wienbruch, B. Rockstroh and E. Taub. 1995. Increased cortical representation of the fingers of the left hand in string players. Science 270: 305–307.
  • Eriksson, P. S., et al. 1998. Neurogenesis in the adult human hippocampus. Nature Medicine 4:1313–1317.
  • Folkman, J., and M. Klzagsbrun. 1987. A family of angiogenic peptides. Nature 329:671–672.
  • Gilbert, C. D. 1996. Learning and receptive field plasticity. Proceedings of the National Academy of Sciences of the USA 93:10546–10547.
  • Goldman, S. A., and F. Nottebohn. 1983. Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain. Proceedings of the National Academy of Sciences of the U.S.A 80:2390–2394.
  • Gould, E., A. J. Reeves, M. S. A. Graziano and C. G. Gross. 1999. Neurogenesis in the neocortex of adult primates. Science 286:548–552.
  • Greenough, W. T. and C. H. Bailey. 1988. The anatomy of a memory: Convergence of results across a diversity of tests. Trends in Neurosciences 11:142–147.
  • Ingvar, D. H. and G. Franzen. 1974. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatrica Scandinavia 50:425–462.
  • Ingvar, D. H., and M. Schwartz. 1974. Blood flow patterns induced in the dominant hemisphere by speech and reading. Brain 97:273–288.
  • Kandel, E. R., and L. R. Squire. 2000. Neuroscience: Breaking down scientific barriers to the study of brain and mind. Science 290:1113–1120.
  • Klose, R. 1920. Das Gehirn eines Wunderkindes (des Pianisten Goswin Sökeland). Monatasschrift fur Psychiatrie und Neurologie 48:83–85.
  • Meyer, A. 1977. The search for a morphological substrate in the brains of eminent persons including musicians: A historical review. In Music and the Brain: Studies in the Neurology of Music, Critchley, M. and R. A. Henson, eds. Springfield, IL: Charles C. Thomas. Pp. 255–281.
  • Miller, E. K., and R. Desimone. 1994. Parallel neuronal mechanisms for short-term memory. Science 263: 520–522.
  • Miller, G. 2005. How are memories stored and retrieved? Science 309:92.
  • Mohammed, A. H., et al. 2002. Environmental enrichment and the brain. Progress in Brain Research 138:109–133.
  • Rakic, P. 1998. Young neurons for old brains? Nature Neuroscience 1:645–647.
  • Schneider, P., et al. 2002. Morphology of Heschl’s gyrus reflects enhanced activation in the auditory cortex of musicians. Nature Neuroscience 5:688–694.
  • Squire, L. R. 2007. Rapid consolidation. Science 316:57–58.
  • Sutton, M. A. and E. M. Schuman. 2006. Dendritic protein synthesis, synaptic plasticity, and memory. Cell 127:4958.
  • Thompson, P. M., et al. 2000. Growth patterns in the developing brain detected by using continuum mechanical tensor maps. Nature 404:190–193.
  • Witelson, S. F., D. L. Kigar and T. Harvey. 1999. The exceptional brain of Albert Einstein. The Lancet 353:2149–2153.
  • Wolf, F., and F. Kirchhoff. 2008. Imaging astrocyte activity. Science 320:1597–1599.

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