MACROSCOPE
Zeroing in on Cancer
As targeted cancer therapies get more specific, the targets get rarer
Carlos F. Amábile-Cuevas
COMPUTING SCIENCE
The Great Principles of Computing
Computing may be the fourth great domain of science along with the physical, life and social sciences
Peter J. Denning
ENGINEERING
Hoover Dam Bypass*
A bridge's design becomes a special challenge when it shares scenery with an engineering icon
Henry Petroski
SLIDE SHOW
Rock Avalanches of the Upper Indus
Human settlements in northern Pakistan depend on the leveling effects of rock landslides. Here we present photographs of the region by Kenneth Hewitt, whose feature article appears in this issue
Kenneth Hewitt