FROM THE EDITOR
Going Viral
Lessons in the reach of social media
David Schoonmaker
MACROSCOPE
Do We Really Need the S-word?
The use of “significance” in reporting statistical results is fraught with problems—but they could be solved with a simple change in practice
Megan D. Higgs
COMPUTING SCIENCE
Imitation of Life
Can a computer program reproduce everything that happens inside a living cell?
Brian Hayes
MARGINALIA
Comments and Corrigenda in Scientific Literature
How self-correcting is the written record of scientific and engineering endeavors?
Joseph Grcar
BOOK REVIEWS
From Plants to Planets: Our Favorite Coffee-Table Books of 2012
Each winter we peruse the year’s large-format science books and present brief reviews of the ones we like best. This year's crop offers plenty of good books to cozy up with