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FEATURE ARTICLE

Why We Develop Food Allergies

Coached by breast milk and good bacteria, the immune system strives to learn the difference between food and pathogens before the first morsel crosses our lips

Per Brandtzaeg

No peanuts. No dairy. No eggs or shellfish or soy. No wheat or corn, no tree nuts or fin fish, no sesame seeds or spices of any kind. Few people have a diet this restrictive, but allergies to foods affect at least 1 in 20 young children and about 1 in 50 adults in industrialized countries. The numbers are rising: According to a recent study, the prevalence of peanut allergy—which accounts for the majority of emergency-room visits and deaths related to food allergies each year—doubled between 1997 and 2002.

Figure 1. Only minutes after being born...Click to Enlarge Image

 The story of food allergy is a story about how the development of the immune system is tightly linked to the development of our digestive tract or, as scientists and physicians usually refer to it, our gut. A human being is born with an immature immune system and an immature gut, and they grow up together. The immune system takes samples of gut contents and uses them to inform its understanding of the world—an understanding that helps safeguard the digestive system (and the body that houses it) against harmful microorganisms.

The many-layered defenses of the immune system are designed to guard against invaders while sparing our own tissues. Food represents a special challenge to this system: an entire class of alien substances that needs to be welcomed rather than rebuffed. An adult may pass a ton of food through her gut each year, nearly all of it distinct at the molecular level from her own flesh and blood. In addition, strains of normal, or commensal, bacteria in the gut help with digestion and compete with pathogenic strains; these good microbes need to be distinguished from harmful ones. The body's ability to suppress its killer instinct in the presence of a gut-full of innocuous foreign substances is a phenomenon called oral tolerance. It requires cultivating a state of equilibrium, or homeostasis, that balances aggression and tolerance in the immune system. Intolerance, or failure to suppress the immune response, results in an allergic reaction, sometimes with life-threatening consequences.





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