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FEATURE ARTICLE

The Growing Threat of Biological Weapons

The terrorist threat is very real, and it's about to get worse. Scientists should concern themselves before it's too late

Steven Block

Assessing the Terrorist Threat

Biological weapons have been called "the poor man's atom bomb." By any measure, the economic outlay required to develop offensive bioweapons capabilities is significantly less than that of a nuclear program. Less is needed in the way of equipment and infrastructure. The materials themselves are less rare. And less is required in the way of specialized knowledge for the biological aspects, since much of the information can be found in the public domain. Worldwide, trained microbiologists overwhelmingly outnumber nuclear physicists. All these aspects tempt not only nations of concern, but also non-state actors. In fact, it seems far more likely that biological agents will be used by terrorists than by warring nations. Although the terrorist use of bioweapons is likely to occur on a reduced scale, it could have worldwide ramifications under unfavorable circumstances.

Little of real consequence has occurred along these lines, but shots have been fired across the bow. In a bizarre episode that took place in September 1984, more than 750 people fell ill with food poisoning in The Dalles, Oregon. Thankfully, no one died. The cause of the epidemic was not uncovered by health authorities at the time. But in 1986, Ma Anand Sheela confessed at trial that she and other followers of the Baghwan Sri Rajneesh had spread salmonella bacteria, grown on the cult's Oregon ranch, in salad bars in four restaurants, all in an effort to keep voters from the polls so as to influence a local election. After serving two and a half years in federal prison, Sheela was released and deported to Europe.

Between 1990 and 1995, the well-financed Japanese apocalyptic cult Aum Shinrikyo launched a repeated series of attacks on civilians using both biological and chemical weapons. These culminated in the infamous sarin gas release inside the Tokyo subway system in March 1995, which left 13 people dead and sent more than 5,000 to the hospital. Before resorting to toxic gas, the group had reportedly attempted, unsuccessfully, to mount attacks with biological weapons on at least nine occasions over a five-year period. Aum Shinrikyo boasted a dozen or so members with biological training and had even gone so far as to buy a 500,000-acre sheep station in Banjawarn, Australia to serve as a site for operations and to carry out tests.

The cult worked to develop biological weapons based mainly on botulinum toxin and anthrax, although some members made an unsuccessful trip to Zaire to obtain Ebola virus. They also attempted, but failed, to acquire the rickettsia Coxiella burnetii, which causes Q fever. In their earliest attempts to carry out biological attacks, members of the cult sprayed home-brewed botulinum toxin on Tokyo streets, near two American airbases in Japan and at the Narita International Airport. All of these attacks failed??most likely because they worked with the wrong strain of C. botulinum (not all natural variants yield equal toxicity) and because their misting device may not have been up to the task. They later switched to anthrax, releasing spores in Tokyo near the Imperial Palace, the legislature and a foreign embassy. These tactics again failed, almost certainly because they used a vaccine strain of B. anthracis. And again, their spraying device may not have worked as intended.

Does this mean that we should all relax, because using bioweapons turns out to be harder than the perpetrators thought? Is the terrorist threat therefore exaggerated, as some have maintained? Those who claim that biowarfare agents can be brewed in a garage by practically anyone with a modicum of training may be guilty of overstating the case, but although there has been no shortage of exaggeration, that doesn't mean we're off the hook.

A lesson from the Aum Shinrikyo case is that any group bent on developing offensive bioweapons capabilities must overcome two significant problems, one biological and the other physical. First, it must acquire and produce stable quantities of a suitably potent agent. For a variety of reasons this is not the trivial task that it is sometimes made out to be. Second, it must have an effective means of delivering the agent to the intended target. For most, but not all, bioweapon agents, this translates into solving problems of dispersal. Programs in both the U.S. and the U.S.S.R. devoted years of effort to perfecting these aspects.

But who is to say that a terrorist group might not find its own way to imperfect solutions? After all, a terrorist works under entirely different constraints. For one thing, there's no requirement for the dispersal to be very efficient, because bioweapons terror attacks are highly leveraged. If anthrax were released haphazardly in a major U.S. city and produced only a handful of cases, the public fear and disruption that would ensue might alone bring about the intended effect. Our public health system simply isn't geared up to handle an outbreak of this kind, which would, for a time, flood emergency rooms. A terrorist group might also be tempted to finesse the dispersal problem and release some contagious disease, with the aim of starting an epidemic or even a worldwide pandemic. Or it might choose to act covertly, perhaps attacking an economic target, such as crops or livestock, rather than a human population. There are many different options.

In my opinion, the terrorist threat is very real, and it's about to get worse. And opinions do count here, because quantitative risk assessment is a practical impossibility. As with nuclear war, successful bioweapons attacks are characteristically "low probability, high consequence" events. The expectation value of the risk is the product of a very small and a very large number, and such numbers carry great uncertainty.





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