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HOME > PAST ISSUE > July-August 2000 > Article Detail

FEATURE ARTICLE

Depression and the Birth and Death of Brain Cells

The turnover of neurons in the hippocampus might help to explain the onset of and recovery from clinical depression

Henriette van Praag, Barry Jacobs, Fred Gage

Acknowledgments

This work was supported by Princeton University and a grant from the National Institute of Mental Health. The authors would also like to thank Steve Forbes, Lynne Moore, Bobbi Miller and Linda Kitabayashi for their excellent technical assistance. Special thanks to Mary Lynn Gage for crucial reading of this manuscript. The authors are grateful for continued support from the Hollfelder Foundation, Robert J. and Claire Pasarow Foundation and a grant and contract from the National Institutes of Health.

Bibliography

  • Eriksson, P. S., E. Perfilieva, T. Bjork-Eriksson, A. M. Alborn, C. Nordberg, D. A. Peterson and F. H. Gage. 1998. Neurogenesis in the adult human hippocampus. Nature Medicine 4:1313–1317.
  • Gould, E., A. Beylin, P. Tanapat, A. Reeves and T. J. Shors. 1999. Learning enhances adult neurogenesis in the hippocampal formation. Nature Neuroscience 2: 260?265.
  • Gould, E., A. J. Reeves, M. S. A. Graziano and C. G. Gross. 1999. Neurogenesis in the neocortex of adult primates. Science 286: 548?552.
  • Jacobs, B. L. 1994. Serotonin, motor activity and depression-related disorders. American Scientist 82: 456?463.
  • Jacobs, B. L., and E. C. Azmitia. 1992. Structure and function of the brain serotonin system. Physiological Reviews 72:165–229.




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