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HOME > PAST ISSUE > May-June 1999 > Article Detail

FEATURE ARTICLE

Gene Therapy

Investigators have been searching for ways to add corrective genes to cells harboring defective genes. A better strategy might be to correct the defects

Eric Kmiec

Acknowledgments

I wish to thank current and former members of my laboratory for their hard work on gene repair, the NIH for funding these projects and Michelle Hoffman for editorial advice.

Bibliography

  • Anderson, S. F. 1992. Human gene therapy. Science 256:808–813.
  • Cohen-Haguenauer, O. 1997. Gene therapy: regulatory issues and international approaches to regulation. Current Opinion in Biotechnology 8:261.
  • Cole-Strauss, A., K. Yoon, Y. Xiang, B. C. Byrne, M. C. Rice, J. Gryn, W. K. Holloman and E. B. Kmiec. 1996. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide. Science 273:1386–1389.
  • Edgar, H., and D. Rothman. 1995. The Institutional Review Board and beyond: future challenges to the ethics of human experimentation. Milbank Quarterly 73:489.
  • Gorman, C. 1998. DNA therapy. Time (March 16) p. 37.
  • Hall, S. J., S.-H. Chen and S. L. C. Woo. 1997. The promise and reality of cancer gene therapy. American Journal of Human Genetics 61:785–789.
  • Kay, M. A., D. Liu and P. M. Hoogerbrugge. Gene therapy. Proceedings of the National Academy of Sciences 94:12747–12748.
  • Kmiec, E. B. 1999. Targeted gene repair. Gene Therapy 6:1–3. [CrossRef]
  • U. S. General Accounting Office. 1996. Scientific Research. Continued vigilance critical to protecting human subjects. Health Education and Human Services Division Report #B259279.
  • Shuster, M. J., and G. Y. Wu. 1997. Gene therapy for hepatocellular carcinoma: progress but many stones yet unturned! Gastroenterology 112:656–658.
  • Verma, I. M., and N. Somia. 1997. Gene therapypromises, problems and prospects. Nature 389:239–242. [CrossRef]




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