It is fascinating to read about the "behind-story" on the development of statins. Though, the discussion seems like a bit of marketing for Lipitor when newer potent statins like Crestor are completely missed out even when they are already several years in the market. While bent on discussing carcinogenetic risk as a concern for statins, the author failed to mention the more relevent complications like liver function derangement or myalgia (dose related drawbacks that pushed the development of newer classes of statins like Crestor). As a sidetrack, the relevance of hyper-triglyceridemia and whether statin monotherapy could replace fibrates (was there any historical intention to do so?) is also omitted.
posted by Leo Sham
September 3, 2008
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