Hydrogen Sulfide would function like other natural biological messanger of endothel. Based on my 54-year-long clinical experience, I state that the evaluation of endothelial function, in every biological system, is realized nowadays also clinically with a simple stethoscope, thanks to Quantum Biophysical Semeiotics. Unfortunately, a large number of physicians ignore or overlook a reliable clinical tool useful in bedside evaluating easily and rapidly endothelial cell functions. In fact, among different techniques to evaluate the endothelium functional capacity, that depend on the amount of radical NO produced and the vasodilatation effect, nowadays there are biophysical-semeiotic methods, applicable on very large scale in a few minutes, even under stress tests. In fact, doctors may nowadays bedside assess the synthesis intensity of endothelial cell radical NO, as well as hydrogen sulfide H2S), physiologically generated by cystathionine -lyase (CSE), in order to recognize both artery alteration and ALL other disorders, in simple way. The percentage of vasodilation immediately after Valsalva’s Manoeuvre, confronting it with the basal value, represents the endothelial functional capacity, that is in relation to the local parenchymal cell functions, according to my Angiobiopathy theory, which complete that of Tischendorf's Angiobiotopy. Taking into account that shear stress is one of the most important stimulants for the synthesis and release of radical NO, the non invasive technique most often used is the transient flow-modulate endothelium-dependent post-ischemic vasodilatation, performed on conductance arteries such as the brachial, radial or femoral arteries. Certainly, shear-stress stimulates e-NO synthesis in healthy individual, as allows me to state Biophysical Semeiotics. In addition, doctors can gather a lot of other information, e.g., after drugs administration. In fact, such as vasodilatation is compared with the vasodilatation produced by drugs that are NO and H2S donors, such as nitroglycerine, called endothelium independent. The vasodilatation is quantified by measuring the arterial diameter with high resolution ultrasonography. Laser-Doppler techniques are now starting to be used that also consider tissue perfusion. One must admitt that such as methods cannot be applied neither in apparently healthy individuals in order to perform primary prevention, neither on very large scale even in diseased subjects. All that accounts for the reason that Microcirculation and Clinical Microangiology under both physiological and pathological conditions, are scarsely known by physicians all around the world, also at universities, unfortunately.
Finally, thanks to Quantum Biophysical Semeiotics, as well as the unknown knowledge of non local realm in biological systems beside the local realm, I recently demonstrated, doctors are able in 1 second to bedside exclude macro- and micro-vessels alteration: in health, “intense” digital pressure, applied upon an artery do not bring about simultaneously aspecific gastric reflex, whereas such as reflex appears in presence of whatever vascular disorder Inherited Real Risk in individuals involved by well-defined Biophysical-Semeiotic Constitutions. For further information, See www.semeioticabiofisica.it).
Sergio Stagnaro MD
Via Erasmo Piaggio 23/8,
16039 Riva Trigoso (Genoa) Italy
Founder of Quantum Biophysical Semeiotics
Who's Who in the World (and America)
since 1996 to 2009
posted by Sergio Stagnaro
January 13, 2010
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